Organonitrogen Compounds
Apexbio Technology LLC MYK-461 1642288-47-8 25mg
MYK-461 is a small-molecule inhibitor interacting directly with cardiac myosin heavy chain to modulate myocardial contraction It specifically reduces myocardial contractility through inhibition of cardiac myosin ATPase enzymatic activity thereby limiting myosin-mediated phosphate release without affecting ADP dissociation rates In rodent cardiomyocytes MYK-461 demonstrates dose-dependent reductions in fractional shortening and sarcomeric force generation without impacting calcium transient dynamics Its inhibitory potency against cardiac myosin ATPase surpasses that observed for skeletal muscle isoforms In preclinical hypertrophic cardiomyopathy mouse models MYK-461 administration attenuates cardiac contractile function facilitating investigations into myocardial contractility regulation and potential therapeutic strategies against hypertrophic cardiomyopathy
eMolecules 201931-70-6 | 4-((HYDROXYAMINO)METHYL)-2-METHOXYPHENOL HYDROCHLORIDE | AstaTech205.640 | C8H12ClNO3 | 95.000 | Cl.COc1cc(CNO)ccc1O | 0.1g | 696745948
4-((HYDROXYAMINO)METHYL)-2-METHOXYPHENOL HYDROCHLORIDE | AstaTech | 201931-70-6205.640 | C8H12ClNO3 | 95.000 | Cl.COc1cc(CNO)ccc1O | 0.1g | 696745948
Medchemexpress LLC Creatine kinase M-type (CKM), human recombinant, His-tagged | 9001-15-4 | >95.0% | 5 UG
Recombinant human creatine kinase M-type (CKM) is supplied as an N-His-tagged, full-length protein expressed in E. coli and provided as a lyophilized powder for research use only. The enzyme catalyzes reversible phosphate transfer between ATP and creatine and is suitable for biochemical activity assays, enzyme kinetics, and assay development.
- Full-length human CKM with N-terminal His tag.
- Expression system: E. coli.
- Approximate molecular weight 45 kDa.
- Purity greater than 95% by reducing SDS-PAGE.
- Reported specific activity ~3604 pmol/min/μg.
- Lyophilized formulation from HEPES buffer for stability.
- Store at -20°C before reconstitution; aliquot and freeze at -20°C or -80°C after reconstitution.
- Intended for research use only, not for clinical or diagnostic use.
![eMolecules 131106-70-2 | Ambeed | 6-(Trifluoromethyl)benzo[d]thiazole | 100mg | 518525230 | A365025 | MFCD06659653 | 203.18 | C8H4F3NS](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502455386.PNG-250.jpg)
eMolecules 131106-70-2 | Ambeed | 6-(Trifluoromethyl)benzo[d]thiazole | 100mg | 518525230 | A365025 | MFCD06659653 | 203.18 | C8H4F3NS
Medchem Express | Berberrubine (chloride) | 5mg | 533802409 | HY-125850 | 15401-69-1 | MFCD01658905 | 357.790 | C19H16ClNO4
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Medchemexpress LLC Steviol | 471-80-7 | 318.45 | 5 MG
Steviol is the main metabolite of steviol glycosides and an inhibitor of AQP2/CFTR. It slows down renal cyst growth by inhibiting CFTR activity, reducing AQP2 expression, and promoting AQP2 and CFTR degradation. It can be used in polycystic kidney disease research.
- Main metabolite of steviol glycosides
- Inhibitor of AQP2/CFTR
- Slows down the growth of renal cysts
- Inhibits CFTR activity
- Reduces AQP2 expression
- Promotes degradation of AQP2 and CFTR
- Can be used in polycystic kidney disease research
- Exerts diuretic, natriuretic, kaliuretic effects
- Inhibits renal tubular reabsorption of glucose
Sigma Aldrich Fine Chemicals Biosciences Creatine Kinase CK from ra
ATPcreatine N-phosphotransferaseCreatine kinase (CK) has a molar mass of 85kDa. It exists as a dimer in the cytosolic form and as a dimer and an octamer in the mitochondrial form. The cytosolic forms are named as MM BB and MB where M and B correspond to muscle and brain respectively. CK from rabbit muscle is a dimer containing two identical polypeptide chains of 380 amino acids. Each subunit has four cysteines Cys73 Cys145 Cys253 and Cys282 but lacks inter- and intra-chain disulfide bonds.
Apexbio Technology LLC Clonidine HCl 4205-91-8 10mM (in 1mL DMSO)
Clonidine Hydrochloride (CAS 4205-91-8) is a synthetic imidazoline derivative that functions as a centrally acting alpha-2 adrenergic receptor agonist By stimulating these receptors in the brainstem clonidine inhibits sympathetic outflow resulting in decreased peripheral vascular resistance and lowered blood pressure In a research context clonidine is frequently used to investigate mechanisms underlying central adrenergic regulation cardiovascular physiology and autonomic nervous system function Its pharmacological profile makes it valuable for studies exploring hypertension neuropharmacology and related therapeutic strategies
Medchemexpress LLC Lumichrome | 50MG
Lumichrome a photodegradation product of Riboflavin is an endogenous compound in humans Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism Lumichrom is the inhibitor for AKT/ -catenin signaling pathway[1][2]
eMolecules 50-01-1 | Guanidine hydrochloride | Chemodex Ltd. | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 100g | 482922230
Guanidine hydrochloride | Chemodex Ltd. | 50-01-1 | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 100g | 482922230
eMolecules 50-01-1 | Guanidine hydrochloride | Chemodex Ltd. | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 500g | 482922231
Guanidine hydrochloride | Chemodex Ltd. | 50-01-1 | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 500g | 482922231
eMolecules 50-01-1 | Guanidine hydrochloride | Chem-Impex | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 250g | 228708822
Guanidine hydrochloride | Chem-Impex | 50-01-1 | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 250g | 228708822
eMolecules 1362243-70-6 | Medchem Express | Fluorizoline | 5mg | 572596564 | HY-114989 | 362.19 | C15H8Cl2F3NS
Ambeed | 56-Difluoroindole | 100mg | 521390953 | A100948 | 169674-01-5 | MFCD01075212 | 153.132 | C8H5F2N
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Medchemexpress LLC VAS 3947 | 869853-70-3 | 99.59% | 310.33 | 50 MG
VAS 3947 is a specific NADPH oxidase (NOX) inhibitor that exerts a potent antiplatelet effect. It induces apoptosis independently of anti-NOX activity, primarily through UPR activation, due to protein aggregation and misfolding.
- Consistently inhibits NADPH oxidase activity in low micromolar concentrations.
- Does not interfere with ROS detection, XOD, or eNOS activities.
- Triggers cell proliferation arrest and death.
- Decreases ROS levels and triggers endoplasmic reticulum (ER) stress and consequent unfolding protein response (UPR).
- Attenuates platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC.
AdipoGen 4Me-indotricarbocyanine PF6
Chemical. CAS 134339-08-5. Formula C35H45F6N2P. MW 638.72. Cyanine dye. Spectral Data lambdaex=747nm lambdaem=774nm. Cyanine dyes were first synthesized over a century ago, used to sensitize photographic plates and comprise a diverse family of fluorophores. With their narrow absorption and fluorescence spectral profiles, together with high oscillator strengths for the lowest-energy absorption transition, these dyes are ideal candidates for fluorescence standards for the far-red region.
Medchemexpress LLC FSL-1 | 322455-70-9 | 99.22% | 1666.16 | 5 MG
FSL-1 is a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to experimental HSV-2 infection. It also reduces HSV-2 replication in human vaginal epithelial cells and induces significant resistance to experimental genital HSV-2 infection through a specific cytokine response profile. Additionally, FSL-1 enhances phagocytosis of bacteria by macrophages via a Toll-like receptor 2-mediated signaling pathway.
- Enhances resistance to experimental HSV-2 infection.
- Reduces HSV-2 replication in human vaginal epithelial cells.
- Induces significant resistance to experimental genital HSV-2 infection.
- Enhances phagocytosis of bacteria by macrophages.